Pitfalls of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant usage of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may possibly bring about a rise in tramadol plasma levels and a minimize within the amounts of the active metabolite, M1.When you receive your